Complement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophages
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چکیده
منابع مشابه
CYCLIC NUCLEOTIDES CONTROL DIFFERENTIATION OF HUMAN MONOCYTES INTO EITHER HIGHLY ACCESSORY CELLS OR MACROPHAGES
Human peripheral blood monocytes have been found to undergo a transitory state of high accessory activity before they fully become macrophages. Time kinetics were done to follow this accessory potential. Studying the regulation of accessory activity, we have found that monocyte derived accessory cells (m-AC) pass through two phases of development, both of which are adversely controlled by ...
متن کاملcyclic nucleotides control differentiation of human monocytes into either highly accessory cells or macrophages
human peripheral blood monocytes have been found to undergo a transitory state of high accessory activity before they fully become macrophages. time kinetics were done to follow this accessory potential. studying the regulation of accessory activity, we have found that monocyte derived accessory cells (m-ac) pass through two phases of development, both of which are adversely controlled by cycli...
متن کاملInhibitor in Human Monocytes and Macrophages
Biosynthesis and secretion of alpha-1-proteinase inhibitor (a1PI) has been demonstrated in primary cultures of human mononuclear phagocytes, making it possible to study regulation of a1PI in normal (PiMM) and homozygous-deficient (PiZZ) individuals. In this study, expression of a1PI by blood monocytes, bronchoalveolar, and breast milk macrophages decreased during 1 wk in culture whereas express...
متن کاملHaemophilus influenzae interacts with the human complement inhibitor factor H.
Pathogenic microbes acquire human complement inhibitors to circumvent the innate immune system. In this study, we identify two novel host-pathogen interactions, factor H (FH) and factor H-like protein 1 (FHL-1), the inhibitors of the alternative pathway that binds to Hib. A collection of clinical Haemophilus influenzae isolates was tested and the majority of encapsulated and unencapsulated boun...
متن کاملA phased strategy to differentiate human CD14+monocytes into classically and alternatively activated macrophages and dendritic cells.
There are currently several in vitro strategies to differentiate human CD14(+) monocytes isolated from peripheral blood mononuclear cells (PBMCs) into the M1 or M2 macrophage cell types. Each cell type is then verified using flow cytometric analysis of cell-surface markers. Human CD14(+) monocytes have the potential to differentiate into M1 and M2 macrophages, both of which demonstrate varying ...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2020
ISSN: 2162-402X
DOI: 10.1080/2162402x.2020.1731135